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Targeting the DNA Damage Response for Cancer Therapy (Cancer Treatment and Research, 186) by Timothy A. Yap, Geoffrey I. Shapiro
English | November 18, 2023 | ISBN: 3031300645 | 338 pages | MOBI | 5.67 Mb
This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic.
Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.
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The 10-Second Customer Journey: The CXO's playbook for growing and retaining customers in a digital world by Todd Unger
English | June 11, 2024 | ISBN: 1788605039 | 184 pages | PDF | 2.27 Mb
You've Got 10 seconds to Win or Lose a Customer. This is the Ultimate Guide to Rapid Conversion in Digital Marketing.
The customer landscape has transformed, and marketers, advertisers, and business owners must adapt to a world where buying decisions are made in seconds, not months or days. The biggest obstacle? FRICTION. Those who can minimize friction and guide potential buyers swiftly through the buying process will triumph. (Hello, Amazon 1-click purchases.)
However, reducing friction requires the seamless integration of marketing, product, e-commerce, and service into a cohesive, friction-free customer experience―a feat that siloed companies struggle to achieve.
Enter The 10-Second Customer Journey. This is your ultimate playbook for capturing rapid conversions and growing your customer list. Todd Unger, Chief Experience Officer (CXO) of the American Medical Association, leverages his three decades of expertise in consumer marketing, advertising, digital products, and digital marketing to offer a step-by-step guide. He'll teach you how to become your own Chief Friction-Reduction Officer, reignite customer growth, and enhance engagement.
Why You Should Read This Book:Conquer the New Digital Experience Landscape: Adapt old marketing concepts to the needs of today's digital customers. UX is king.Identify and Target the Right Customers: Discover how to pinpoint your ideal audience and convert them into loyal customers quickly.Test and Optimize Your Approach: Master the art of testing various strategies to find the most effective way to reach and engage your customers.Written in an engaging style and packed with original insights, this is a must-read for current and aspiring marketers, customer experience leaders, and digital executives aiming to build robust customer experience strategies for their brands and organizations.
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The Adolescent Athlete: A Practical Approach By Lyle J. Micheli MD, Laura Purcell MSc, MD, FRCPC, FAAP, Dip Sport Med (eds.)
2007 | 444 Pages | ISBN: 0387359648 | PDF | 29 MB
The Adolescent Athlete: A Practical Approach offers keen insight into providing musculoskeletal care for growing athletes. Chapters are logically organized by anatomical region and are written by experts in the field who focus on improved clinical decision making. Intended for sports medicine physicians, primary care physicians, orthopedists, and athletic trainers, the text addresses both chronic and acute injuries in addition to congenital conditions. Fundamentals, including basic anatomy, physical examination, and patient history are covered in detail. Emphasis is placed on the recognition of injury patterns unique to adolescent athletes, and invaluable tables are incorporated to assist with diagnosis. Prevention, patient management, and referral are outlined. The user-friendly book also highlights return to play guidelines and includes summary pearls. To further facilitate comprehensive patient care, musculoskeletal diagnostic imaging and principles of rehabilitation are covered as well. Anatomical drawings, photos of examination maneuvers, and diagnostic images, such as x-rays and MRI scans, complete the text by illustrating key concepts. With its presentation of sought-after information and accessible format, this book is a welcome resource for those who want to improve the musculoskeletal health of active children and adolescents.
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The Ambitious Kitchen Cookbook: 125 Ridiculously Good for You, Sometimes Indulgent, and Absolutely Never Boring Recipes for Every Meal of the Day by Monique Volz
English | September 17th, 2024 | ISBN: 0593581652 | 288 pages | True EPUB | 121.52 MB
The recipe queen, social media star, and beloved blogger behind the popular recipe websiteAmbitiousKitchenpresents over 125 nutrient-dense, flavor-packed recipes for every meal of the day.
"Monique effortlessly combines creativity with approachability, ensuring each dish is a success. This book is an instant classic for me!"-Alex Snodgrass, New York Times bestselling author and creator of The Defined Dish
Millions of readers know Monique Volz's website, Ambitious Kitchen, as a go-to resource for inventive, flavorful recipes that are full of nutrition, comfort, and personality. Now, in her debut cookbook, Monique wants others to find their own Ambitious Kitchen and discover their own version of health, bold flavors, and above all, the unique happiness that food can bring to your life. Whether you're looking for a show-stopping dish to bring to a gathering, a new home-cooked tradition, or a nourishing meal everyone will love, The Ambitious Kitchen Cookbook has the answers.
Monique joyfully showcases a balanced approach to health, with comforting, vibrant dishes that are amped up with extra vegetables, protein, and fiber. Wake up and sip on a Glowing Skin Vitamin A Smoothie or bake The Best Cinnamon Rolls You'll Ever Eat for someone you love. Enjoy nutritious lunches such as Buffalo Chicken Chop Chop Salad or Roasty Toasty Tomato Soup with Herbed Grilled Cheese Naan. Family dinner might look like It's a Sheet Pan Honey Mustard Chicken, Sweet Potato & Bacon Situation or Pepperoni Pizza Baked Orzo with Basil and Quick Hot Honey on a busy night, or Everyone's Favorite Baked Chicken Tacos or Marry Me Ropa Vieja for a crowd. And let's not forget show-stopping desserts like Tahini Pumpkin Cake with Brown Butter Cream Cheese Frosting and outrageously good Double Strawberry Oatmeal Cream Pies (Little Debras).
Most recipes include "Make It Your Way" and "Make It Nutrient Dense" tips to customize food to your tastes. And as an added bonus, most can be made gluten-free, dairy-free, or vegan, allowing readers to tailor recipes to their own version of health.
As you turn the pages, you'll find yourself a guest at Monique's table, enjoying playful, comforting recipes that will impress everyone (including yourself!).
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The Backyard Stargazer's Bible: Discover Constellations, Galaxies, Nebulae, Meteorites, and More by Ian Ridpath, Mary McIntyre, Rachel Federman
English | September 17th, 2024 | ISBN: 1419773887 | 416 pages | True EPUB | 100.78 MB
A comprehensive and eye-catching resource for backyard stargazers of all levels packed with absolutely everything you need to follow the progress of constellations, night sky events, and celestial facts.
Foreword by Dr. Stephen Maran
A sumptuous aesthetic is paired with practical tips from experts on charting lunar phases and celestial events, notable astronomical anniversaries and facts, the best equipment for stargazing and particular events for your location complete with maps, and much more, packaged into a beautiful, illustrative gift book.
Never miss a night sky event wherever you are in the world, go meteor‑spotting, and track phases of the moon, constellations, and planetary events. Discover Dark Sky Sites and what we can learn from reducing light pollution. Get to know the Moon's features and phases, constellations, comets, planetary bodies, eclipses, conjunctions, and more. Find out what you can see with the naked eye and the wider canvas of a telescope.
With The Backyard Stargazer's Bible, you'll embrace the magnificent splendor of the rich tapestry of the skies above.
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Noel Botham, "The Best Book of Useless Information Ever"
English | 2007 | ISBN: 1844541754 | EPUB | pages: 224 | 0.3 mb
Hot on the heels of the sensational success of the World's Greatest Book of Useless Information, the Official Useless Information Society bring you another essential compendium of everything you never needed but always wanted to know. Were you aware, for example, that cigarettes contain honey? Or that a ferret will die if it cannot find a mate? Would you like to know what Madonna did before she was famous, or how many toothpick accidents there are every year. If you are a lover of the wonderfully pointless, then this is the book for you.
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Philip Kaplan, "The Bird Farm: Carrier Aviation in WWII and Since"
English | 2015 | ISBN: 1634504828 | EPUB | pages: 240 | 36.1 mb
See the excitement and danger of life on an aircraft carrier like never before.
How does it feel to sit aboard a thirty-ton jet and be hurled over a ship's bow at 140 miles per hour? And how does a deck crew coordinate its efforts to achieve such a feat every thirty seconds?
Offering a rare glimpse of life aboard an aircraft carrier, The Bird Farm paints a vivid and often hair-raising portrait of military aircraft carriers and carrier crews, and of the planes and pilots who depend on them. Based on archival research and interviews with veterans and contemporary carrier personnel, this stunning volume tells the story of the aircraft carrier-from the first ramshackle seaplane carriers to today's nuclear-powered supercarriers-and celebrates their undeniable impact on modern warfare.
Skyhorse Publishing, as well as our Arcade imprint, are proud to publish a broad range of books for readers interested in history-books about World War II, the Third Reich, Hitler and his henchmen, the JFK assassination, conspiracies, the American Civil War, the American Revolution, gladiators, Vikings, ancient Rome, medieval times, the old West, and much more. While not every title we publish becomes a New York Times bestseller or a national bestseller, we are committed to books on subjects that are sometimes overlooked and to authors whose work might not otherwise find a home.
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The Blue Plate: A Food Lover's Guide to Climate Change by Mark J. Easter
English | September 17th, 2024 | ISBN: 1952338204 | 400 pages | True EPUB | 41.77 MB
Do you really know what's for dinner? The Blue Plate is the perfect dinner companion for food lovers who also care about the planet.
Ecologist Mark J. Easter offers a detailed picture of the impact the foods you love have on the earth. Organized by the ingredients of a typical dinner party, including seafood, salad, bread, chicken, steak, potatoes, and fruit pie with ice cream, each chapter examines the food through the lens of the climate crisis. Gathered like guests around the table, here are the stories of these foods: the soil that grew the lettuce, the farmers and ranchers and orchardists who steward the land, the dairy and farm workers and grocers who labor to bring it to the table. Each chapter reveals the causes and effects of greenhouse gas emissions, as well as the social and environmental impact of out-of-season and ar-from-home demand.
What can you do to eat more sustainably? Food lovers everywhere will be happy to know that the answer is not necessarily a plant-based diet. For each food group, Easter offers low-carbon, in-season alternatives that make your favorite foods not only more sustainable but also more delicious.
The first step, however, is an understanding of how food is grown, produced, harvested, and shipped. In stories both personal and entertaining, the author offers a full understanding of what's for dinner.
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Brenda Lange, "The Caribbean Community (Global Organizations)"
English | 2009 | pages: 129 | ISBN: 079109541X | PDF | 4,8 mb
Provides readers with historical background-complete with sidebars and a list of further resources-to understand some of the most influential, and sometimes controversial, organizations around the world that can affect economic, political, or social change.
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The Certainty Trap
by Ilana Redstone
English | 2024 | ISBN: 1634312562 | 248 pages | True EPUB | 5.71 MB
When we're in the Certainty Trap, we tend to view people who disagree with us as hateful, ignorant, or just plain stupid. When it comes to heated social and political issues in particular, many of us know this feeling well-a consuming state of righteous indignation and moral outrage. And this response makes sense because our very certainty tells us that there are simple and obvious causes and solutions to the hot-button issues we care about most. But the things we care about the most are-far more often than not-morally and ethically complex. If the problems that divide us are inherently complicated, then a sense that the answers are obvious-and that anyone who disagrees must be deficient in some way-is misplaced. It's an oversimplification that both leads to and reflects faulty thinking. When we're certain, we not only fail to recognize the possibility that we're wrong but also fail to be clear about the principles and values that drive our disagreement in the first place. By committing to challenging and clarifying our thinking-by avoiding the trap certainty sets for us-we can increase social trust, reduce political polarization, and better address the world's pressing challenges.
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The Coming Storm: A Journey into the Heart of the Conspiracy Machine by Gabriel Gatehouse
English | 5 Sept. 2024 | ISBN: 1785948156, 1785948164 | True PDF | 384 pages | 2.4 MB
Is this how democracy dies?
The Coming Storm is Gabriel Gatehouse's brilliant exploration of how conspiracy theories are tearing America apart. It's a story that takes you down a rabbit hole - one that both the US as a nation and he as a journalist fell through - to unpack an epochal shift in political culture that starts in the earliest years of the Clinton administration and reached a crescendo on 6 January 2021 with the storming of the US Capitol. But that event wasn't the wild finale of a chaotic Trump presidency many hoped for - it was only the beginning.
A compelling mix of research and reportage, The Coming Storm gets under the skin of these conspiracy theories to show us a radical new kind of politics emerging, a movement that has coalesced around a loose alliance of tech bros, internet trolls and white supremacists. At a perilous moment in the history of American democracy, Gatehouse tells us some dark truths about our present, and provides clues about our future. The Coming Storm marks the debut of a major new voice in political journalism.
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The Conceptions of Reality in the Interpretations of Quantum Mechanics: A Journey from Aristotle's Principles to Einstein's Dreams of a Unified Theory by Gerd Christian Krizek
English | PDF EPUB (True) | 2024 | 169 Pages | ISBN : 3031657853 | 21.3 MB
This book explores the different conceptions of reality in the various interpretations of Quantum Mechanics, demonstrating the intimate connection to philosophy of physics. With interest in the foundations of Quantum Mechanics having revived in recent decades, a number of interpretations have been formulated or rediscovered and these remain in strong competition with one another for acceptance by the scientific community. At the same time they imply quite different notions of reality.
The author provides an overview of these conceptions of reality and their embedding in physical theories, interpretations of Quantum Mechanics and related philosophical frameworks.
Starting with Aristotle's principles, the deep fruitful connection between philosophy and physics guides this journey through the foundations of Quantum Mechanics.
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Gordon Cullen, "The Concise Townscape"
English | ISBN: 0750620188 | | 200 pages | PDF | 60 MB
This book pioneered the concept of townscape. 'Townscape' is the art of giving visual coherence and organization to the jumble of buildings, streets and space that make up the urban environment. It has been a major influence on architects, planners and others concerned with what cities should look like.
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The Conversion of Liquid Rocket Fuels: Risk Assessment, Technology and Treatment Options for the Conversion of Abandoned Liquid Ballistic Missile Propellants (Fuels and Oxidizers) in Azerbaijan By Steve Brown (auth.), Wolfgang P. W. Spyra, Kay Winkelmann (eds.)
2005 | 148 Pages | ISBN: 1402023804 | PDF | 3 MB
Prof. Dr. -Ing. Wolfgang Spyra Brandenburg University of Technology in Cottbus, Germany The demilitarization and conversion of military properties wor- wide has been a topic of growing importance since the end of the Cold War. The slowing of the arms race brought on by weapons treaties and relaxed tensions between NATO and Warsaw Pact nations caused sto- piles of conventional weapons to become superfluous. The need to process and dispose of such weapons began more quickly in NATO countries. This demilitarization process began shortly after the reunification of Germany and was largely completed by the mid to late 1990's. The remaining process, no small task in itself, of converting lands formerly used by the military into safe and environmentally acceptable landscapes may continue for decades to come. Due to a lack of resources and technology, the process of demilitarization in the former Warsaw Pact countries has launched more slowly. In 2002 both Georgia and Moldova finished projects which destroyed their stocks of liquid ballistic missile components. Both these projects were carried out through the cooperative support of trans-national organizations, private contractors, and research institutions. The Republic of Azerbaijan now finds itself at the beginning of its demilitarization process. Stored at the country's military depots are over 2000 tons of missile fuels, oxidizer, and chemical additives. This hazardous waste is kept in tanks intended only for temporary transport and storage.
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Susan Fenty Studham, "The Dance and Opera Stage Manager's Toolkit: Protocols, Practical Considerations, and Templates "
English | ISBN: 0367566575 | 2024 | 208 pages | PDF | 58 MB
The Dance and Opera Stage Manager's Toolkit details unique perspectives and approaches to support stage managers beginning to navigate the fields of dance and opera stage management in live performance.
This book demystifies the genre-specific protocols and vocabularies for stage managers who might be unfamiliar with these fields and discusses common practices. Filled with valuable industry-tested tools, templates, and practical information, The Dance and Opera Stage Manager's Toolkit is designed to assist stage managers interested in pursuing these performance genres. The book also includes interviews and contributions from a range of professional stage managers working in dance and opera.
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Michael Sierra-Arévalo, "The Danger Imperative: Violence, Death, and the Soul of Policing"
English | ISBN: 0231198469 | 2024 | 368 pages | PDF | 6 MB
Winner, 2024 Distinguished Book Award, Sociology of Law Section, American Sociological Association
Winner, 2024 Outstanding Book Award, Division of Policing, American Society of Criminology
Policing is violent. And its violence is not distributed equally: stark racial disparities persist despite decades of efforts to address them. Amid public outcry and an ongoing crisis of police legitimacy, there is pressing need to understand not only how police perceive and use violence but also why.
With unprecedented access to three police departments and drawing on more than 100 interviews and 1,000 hours on patrol,
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The Earth Mysteries Workbook
by Greer, John Michael;
English | 2024 | ISBN: 1801521212 | 268 pages | True EPUB | 6.47 MB
A practical and investigative workbook to explore the timeless enigmas of the land on which we walk
The Earth Mysteries Workbook invites readers to embark on a journey to understand and restore the ancient enchantments of the land, as well as continuing to train the minds and spirits of those engaged in magical study.
The book follows forty-eight lessons which span the course of one year. It is not intended to be read cover to cover; instead readers should take a lesson a week, each of which provides material for thought, study and meditation. Each week is divided into seven numbered paragraphs to be used as themes for the week's daily meditation. The lessons include an introduction to the earth mysteries and natural philosophy, exploration of different sites across the earth, myths and legends, phenomena and much more.
This fourth instalment of John Michael Greer's instructional workbook for members of the Golden Section Fellowship, presents the scholarship of earth mysteries as a fundamental discipline of occult studies and as a spiritual discipline. Greer situates the mysteries of the land as intrinsically linked to occult studies, as they challenge the modern paradigm which ignores and belittles the sacred knowledges of ancient times, sharing a belief in the importance of the past in understanding the subtle and spiritual dimensions of the earth.
This book can be read as an accompaniment to Greer's previous titles, The Way of the Golden Section, The Occult Philosophy Workbook and The Way of the Four Elements.
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Alix Olson, "The Ends of Resistance: Making and Unmaking Democracy"
English | ISBN: 0231204981 | 2024 | 200 pages | PDF | 972 KB
Since the rise of Donald Trump and other right-wing authoritarians worldwide, we have been told to "resist." But this kind of opposition looks surprisingly like restoring the status quo. Under the banner of resistance, liberals and progressives have encouraged voting for Democrats, reading the mainstream media, trusting the science, putting up yard signs, buying the right products, and celebrating a "return to normal." How was "resistance" diluted, and where can we find alternative forms of resistance for present and future struggles?
Alix Olson and Alex Zamalin offer a clear-eyed critical account of how neoliberalism has redefined resistance to thwart social movements and consolidate power. Elites have domesticated and coopted some once-radical concepts and practices into "restorative resistance" that bolsters support for an unjust social order while marginalizing, racializing, and criminalizing many others. Olson and Zamalin argue that true resistance to racial neoliberalism must instead be deeply antirestorative: collective, horizontal, counterhegemonic, radically democratic insurrectionary movements that cannot be redirected into shoring up the existing order. This "unruly world-building"―exemplified by Occupy Wall Street, the Movement for Black Lives, Indigenous activism at Standing Rock, and more―pushes us to live, think, and dream beyond profit maximization, democratic civility, and individual freedom. Powerfully and accessibly written with manifesto-like urgency,
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The Escher Man by T. R. Napper
English | September 17, 2024 | ISBN: 1803368152 | True EPUB | 368 pages | 2 MB
A cartel enforcer across South-east Asia must escape a world of paranoia and violence to save his family in this cerebral and multi-layered cyberpunk science fiction novel, from the award-winning author of 36 Streets. Perfect for fans of William Gibson's The Peripheral and Five Minds by Guy Morpuss.
Your name is Endel 'Endgame' Ebbinghaus. It is Saturday, 3 September, 2101. You're head of security for Mister Long, boss of the Macau Syndicate, a drug cartel. Your memories are being wiped and re-written. You keep this log because you're hard pressed to remember what day it is. But today is a special day, mate. This is your last day on the job."
'Endgame' is a violent man, the perfect enforcer. But Endel is also a father and husband, haunted by the memories of his estranged family, and the life they once had.
Endel wants them back, and he wants out. But life in the syndicate isn't one you can simply leave.
Endgame is a violent man. Or is he? In a world where memory manipulation is the weapon of choice for the powerful, Endel can't tell friends and enemies apart anymore, can't be sure if he's a person or a tool.
Trapped in a taut, twisting nightmare, Endel must find a way to escape the labyrinth they've made of his mind, and take revenge.
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The Gangs Of Zion: A Black Cop's Crusade In Mormon Country by Ron Stallworth
English | September 17, 2024 | ISBN: 1538765942 | True EPUB | 288 pages | 0.7 MB
New York Times bestselling author of Black Klansman, Ron Stallworth, returns with another firsthand account of trailblazing police work in the most unlikely place for a Black cop in the '90s.
Determined to pursue his passion for undercover work wherever it leads, Ron Stallworth finally lands in Salt Lake City, Utah. Once again, he's an outsider-not only as a Black man on a mostly white police force but also as an unapologetic nonbeliever in a state dominated by the Church of Jesus Christ of Latter-Day Saints. But soon after his first drug bust in the Beehive, Stallworth makes a startling discovery-Bloods and Crips are infiltrating Mormon Country, threatening to turn the deeply conservative community into a hotbed of crime. Kids are bombing homes while carrying pocket versions of the Book of Mormon, yet his fellow cops are in denial that gangs are wreaking havoc in their Christian town.
Now Stallworth has a new mission. Whether facing off with skinheads at a downtown bar or schooling white Crips blasting "F*ck tha Police," he is intent on stemming the tide of gangs into the state. But those he expected to be his allies either have their heads in the sand or their own agendas-from the racist Mormon legislator to the community activist exploiting a fatal gang incident to spread paranoia over an imaginary race war.
As he butts heads with these so-called leaders, Stallworth also realizes that gangsta rap has the key to the g-code. He becomes obsessed with-even defensive of-the music he once loathed and puts himself on the front lines of America's culture war. Now he's spitting uncensored lyrics before Congress and taking the stand in the 1993 murder case that puts hip-hop on trial.
But the more Stallworth speaks truth to power, the more determined the gatekeepers in Utah are to silence him, and not even twenty-three years of police work could prepare him for how low they would stoop.
Код:
Rapidgator
https://rg.to/file/21ab0b755306e0aa5bfc823deb30b29c/yky2e.rar.html
TakeFile
https://takefile.link/3m8s9yxp0qa0/yky2e.rar.html
Fikper
https://fikper.com/AZwXP3s5bR/yky2e.rar.html